This depends on the regime of employment of your domestic help:
Regular employment directly by you in your home
YES, even if you only have domestic help for a few hours a week, you must register with Social Security from the first hour of work. This is also the most important obligation for the employer, as non-compliance can lead to financial penalties. Also, if a trial period is agreed, the domestic employee must also be registered during this period.
If you book a cleaning company, you don't need to proceed with the registration with Social Security as the cleaning company is then responsible for the registration.
The new portal of the Social Security Treasury Import@ss offers all the information you need to proceed with all the legal formalities to register your person directly on the portal.